Tizanidine is used to treat muscle spasms caused by conditions such as multiple sclerosis, brain injury, or spinal cord injury. It is a fast-acting muscle relaxant that works by slowing the action in the brain and nervous system. However, a few things to note when taking this drug are how long does Tizanidine stay in your system?
Let’s first start by understanding Zanaflex half-life and how much longer it will stay in the system.
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Zanaflex half-life refers to the time needed for a drug’s concentration in plasma to be reduced by a percentage of 50%. After the half-life of Zanaflex takes place, the drug’s level in the system will be only half of the initial dose and will help people understand how long Tizanidine lasts.
After administering either a tablet or a capsule of Zanaflex, the peak plasma concentrations of the drug take place one hour after ingestion. The half-life is about two hours to two hours and a half. Almost 95% of a dose is metabolized. The metabolites of Tizanidine are not known to be active, with a half-life varying between 20 and 40 hours.
Food does not influence Zanaflex half-life, but it does affect the peak plasma concentration. In fasting conditions, the peak plasma concentration is one hour after ingestion and has a half-life of around two hours. However, the plasma concentration rises by 30% to one hour and 25 minutes when administered with food.
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Knowing the half-life of Tizanidine can help in a possible Tizanidine drug test but also helps the individual to avoid any possible unpleasant withdrawal symptoms if the medication is quit cold turkey. That is why it is important to talk to the doctor or a specialist from a recovery facility regarding any concerns about a possible dependence on this drug. Consult the doctor immediately if faced with hypotension, dry mouth, dizziness, or other symptoms. The doctor might consider replacing the medication with another one.
Any individual can access effective treatment for addiction to drugs in specialized facilities all over the country.
PRESCRIBING INFORMATION. Zanaflex Capsules. U.S. Food And Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/020397s021,021447s002lbl.pdfMagnetic molecularly imprinted polymer nanoparticles for selective solid-phase extraction and pre-concentration of Tizanidine in human urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. https://www.ncbi.nlm.nih.gov/pubmed/26744788Barras, M., & Legg, A. (2017). Drug dosing in obese adults. Australian prescriber, 40(5), 189–193. https://doi.org/10.18773/austprescr.2017.053National Library of Medicine, Tizanidine, 2015 https://medlineplus.gov/druginfo/meds/a601121.htmlZANAFLEX- Tizanidine hydrochloride capsule ZANAFLEX- tizanidine hydrochloride tablet Acorda Therapeutics, Inc. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=413ee468-c7e8-4283-8e2b-b573dcc1f607