Medically reviewed by Alan Carter, Pharm.D. — Written by Jill Seladi-Schulguy, Ph.D. on December 19, 2018

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Acetaminophen (Tylenol) and ibuprofen (Advil) are both over-the-respond to (OTC) medicines that deserve to be used to relieve pain.

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These drugs are 2 different types of pain relievers. Acetaminophen, occasionally detailed as APAP, is its own type, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID).

Normally, it’s safe to take acetaminophen and also ibuprofen together, yet you’ll desire to pay cshed attention to just how much you take of each medication.

The crucial to safely taking acetaminophen and also ibuprofen is learning just how a lot you’re taking at a time and also exactly how frequently.

Acetaminophen dosage

The maximum safe dosage of acetaminophen for anyone over the age of 12 is 4,000 milligrams (mg) per day. But even this amount deserve to damage some people’s livers, so aim for no even more than 3,000 mg per day.

For children under the age of 12, it’s finest to examine through their healthcare provider to identify the safest dose for their body weight.

Keep in mind that many OTC drugs contain acetaminophen in a selection of doses, usually 325 mg, 500 mg, or 650 mg.

Some examples of brand-name OTC drugs that might contain acetaminophen include:


Remember: When looking at labels, you might also check out acetaminophen detailed as APAP.

Ibuprofen dosage

Avoid taking more that 1,200 mg of ibuprofen in a solitary day. OTC ibuprofen is regularly uncovered in 200 mg pills. This equates to 6 pills a day. Still, you have to always verify just how much is in each pill.

Aacquire, for children, it’s best to ask their healthcare provider around the safest dose for their weight.

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If you have actually prescription-stamina ibuprofen, talk to your prescriber prior to mixing it through any kind of other medications, consisting of acetaminophen.


The recommended boundaries for adults and children over 12 are:

3,000 mg per day of acetaminophen1,200 mg per day of ibuprofen

For youngsters under the age of 12, contact their healthtreatment provider or describe the product label for dosage guidelines.

You can take ibuprofen and acetaminophen at the same time. Just make sure to not take more than the recommfinished dose.

Some civilization suffer some stomach or abdominal pain when taking the 2 medicines together. In this instance, it’s much better to different as soon as you take each medication.

For example, you might take ibuprofen initially, adhered to by acetaminophen four hrs later, and also then repeat this procedure as necessary.

You can likewise alternate days. For example, if you take ibuprofen on Monday, take acetaminophen on Tuesday and also so on.