Study objective: we evaluate the analgesic and side effects of adding cyclobenzaprine come ibuprofen in emergency department patients through acute myofascial strain. Methods: A randomized, prospective, double-blind study was performed at an metropolitan teaching ED with an yearly census of 44,000. One hundred 2 patients age 18 to 70 years v acute myofascial strain resulted in by boy trauma within the prior 48 hrs were included, and also 77 patients completed the protocol. Every patient got a solitary dose that 800 mg of ib frames in the ED and also a vial the 6 capsules comprise 800 mg of ib frames to take every 8 hrs as essential after discharge native the ED. In addition, 51 patients obtained a solitary dose that 10 mg of cyclobenzaprine and also a vial that 6 capsules containing 10 mg of cyclobenzaprine to take it every 8 hrs as needed after discharge indigenous the ED; the continuing to be 51 patients received an identically labeling placebo capsule and vial of placebo capsules to take every 8 hours as required after discharge native the ED. Patient rated the soot of their pain top top a 100-mm intuitive analog scale (VAS) at baseline; 30, 60, 90, 120, and 180 minutes; and 24 and also 48 hours after treatment. Call follow-up was obtained at 24 and 48 hours, and side results were elicited at 24 and 48 hours by method of open-ended questioning. Results: The patients in each group were similar with regard to diagnosis and also baseline pain score. The variety of patients that did not finish the protocol and the variety of those who required added analgesia were comparable in both groups. Over the 48 hours of the protocol, the average VAS score because that the mix group decreased from 60.4 come 35.6, and the median VAS score because that the ib frames alone group diminished from 62.2 to 35.4. The mean VAS scores between groups throughout time was not statistically far-reaching (P =.962, repeated-measures analysis of variance). At both 24 and 48 hours, central nervous mechanism side effects were reported more frequently in the patients receiving cyclobenzaprine (16 <42%> versus 7 <18%> at 24 hours and 15 <39%> versus 5 <13%> in ~ 48 hours, respectively). Conclusion: In ED patients v acute myofascial strain, the addition of cyclobenzaprine come ibuprofen go not boost analgesia yet is associated with a greater prevalence of main nervous device side effects. <Ann Emerg Med.

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☆Supported through the Pittsburgh Emergency Medicine structure and the Emergency medicine Association the Pittsburgh.


The writer report they have actually no financial attention in the product studied or the agency that to produce it.

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Address because that reprints: Michael A. Turturro, MD, room of Emergency Medicine, The Mercy Hospital that Pittsburgh, 1400 Locust Street, Pittsburgh, PA 15219; E-mail


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